This high octane thriller focuses on Lucas, (Sam Worthington), a solitary assassin, hired to kill a young woman, Ella, (Odeya Rush). When he can't bring himself to pull the trigger the plan falls apart, setting in motion a twisted game of cat and mouse. Now both are marked for death and forced to form an uneasy alliance. Relentlessly pursued across Europe, their only hope for survival is to expose those responsible for brutally murdering her family and bring them to justice.

CIA chief Hunley (Baldwin) convinces a Senate committee to disband the IMF (Impossible Mission Force), of which Ethan Hunt (Cruise) is a key member. Hunley argues that the IMF is too reckless. Now on his own, Hunt goes after a shadowy and deadly rogue organization called the Syndicate.